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Our paediatric haematology, blood and marrow transplantation unit at St Mary’s Hospital specialises in the care of children with haemoglobinopathies and red cell disorders, bone marrow transplantation and bone marrow failure syndromes.

We provide a comprehensive service for the medical management of children with sickle cell disease and thalassaemia, including a dedicated teenage and young adult transition service. We are the specialist haemoglobinpathy centre in the Paediatric Imperial Red Cell Network, providing tertiary services to local patients and outreach services to haemoglobinopathy patients at hospitals across north west London and the Thames Valley.

The Trust’s paediatric haemoglobinopathy service was ranked the top provider in terms of meeting national quality standards by the West Midlands Quality Review Service in their 2014–16 peer review of services for haemoglobin disorders. We have excellent ’cradle to adult’ care pathways for children with haemoglobin disorders, with robust transition services.

The bone marrow transplant unit has four dedicated transplant cubicles with HEPA filtration and positive pressure control. It carries out 34 to 37 allogeneic transplants a year (both related and unrelated donors) in children with thalassaemia, sickle cell disease, aplastic anaemia, Diamond Blackfan anaemia, Fanconi anaemia, dyskeratosis congenita and other inherited bone marrow failure syndromes. The transplant team has undertaken several innovative transplants using alternative donors for children with haemoglobinopathies and bone marrow failure.

After discharge from the inpatient ward, children are looked after by an expert multidisciplinary team on a dedicated, purpose-built day care unit which is reserved for immunocompromised patients and includes facilities for protective isolation. We also have a comprehensive and dedicated joint specialist service for long-term follow up for recepients of a bone marrow transplant with a consultant haematologist and consultant endocrinologist.

Our service includes the only level two shared care paediatric oncology unit (POSCU) in north west London and sees 20 to 25 new patients with malignancies each year. Patients are looked after by a specialist team led by paediatric haematology consultants with paediatric oncology clinical nurse specialists, in close association with Great Ormond Street Hospital and University College London Hospital. We offer all aspects of supportive care and day care chemotherapy for children.

The service also manages children with bleeding disorders and thrombotic problems. We offer specialist paediatric transfusion advice and provide high-level shared care for children with malignancies.

Conditions we treat

The team provides specialised care for:

  • haemoglobinopathies – sickle cell disease and thalassaemia
  • bone marrow failure
  • bone marrow transplantation
  • paediatric oncology
  • general paediatric haematology
  • haemostasis and thrombosis

Treatments we offer

  • Bone marrow transplants – sibling and matched family donor transplants, alternative donor transplants with unrelated matched and mismatched transplants, haploidentical transplants
  • Level two care for paediatric oncology patients, including infusional, day care and bolus chemotherapy, supportive care and blood product transfusions
  • Tertiary care for patients with haemoglobin disorders, including automated red cell exchange transfusions (erythrocytaphaeresis), top-up blood transfusions, hydroxycarbamide and iron chelation therapy, surgery, paediatric intensive care and 24 hour paediatric emergency department.

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