Mr Farid Froghi Consultant HPB surgeon

Background

Mr Farid Froghi is an academic consultant hepatobiliary and pancreatic (HPB) surgeon at Imperial College London NHS Trust. He specialises in minimally invasive / robotic HPB surgery, liver transplantation, and acute care surgery. He holds a PhD and is a fellow of the Royal College of Surgeons of Edinburgh (FRCSEd).

After completing his undergraduate training at Imperial College School of Medicine, Farid undertook comprehensive specialist training in HPB and liver transplant surgery. He has extensive operative experience in liver and pancreatic resections, liver transplantation, and multi-organ retrieval. He further sub-specialised by completing the Royal College of Surgeons post-CCT fellowship in robotic HPB surgery.

In addition to his clinical work, Farid completed a clinical research fellowship. His PhD focused on ischaemia-reperfusion injury in organ transplantation and perioperative fluid physiology. He has served as a national steering committee member for the ASGBI PANC Study and an NIHR associate principal investigator for the NIHR RfPB funded GAP trial (goal-directed fluid therapy in acute pancreatitis). His research has been recognised with several awards, including the BJS Prize at the ASGBI annual congress.

Farid is also committed to medical education, serving as a mentor for the RCSEng mentoring programme and having previously been awarded Best Tutor of the Year.

Qualifications:

• MBBS, Medicine and Surgery, Imperial College London
• BSc, Gastroenterology and Hepatology, Imperial College London
• PgDip, Trauma Sciences, Queen Mary University of London
• PhD in HPB and Liver Transplantation, University College London
• FRCSEd, General and HPB Surgery, Royal College of Surgeons of Edinburgh

Expertise

Pancreatic cancer, colorectal liver metastasis, hepatocellular cancer, cholangiocarcinoma, liver cirrhosis, acute pancreatitis, gallstones and biliary disease, hernia

Research & publications

Mr Froghi's research interests centre on:

• Hepatobiliary oncology – particularly cholangiocarcinoma management, robotic resection techniques, and liver-directed therapies
• Acute pancreatitis – epidemiology, early management strategies, and goal-directed fluid therapy
• Perioperative fluid physiology – cardiac output-guided fluid therapy and the endothelial glycocalyx
• Minimally invasive and robotic HPB surgery – learning curves and technical innovation
• Transplantation – perioperative optimisation, ischaemia-reperfusion injury, and novel immunological aspects
  
  

Selected recent publications:

Review articles:

Liver transplantation in the management of cholangiocarcinoma: Evolution and contemporary advances. World J Gastrointest Onc. 2023; 15(4):1969–1981. Available at: https://pubmed.ncbi.nlm.nih.gov/37155529/

Stereotactic radiotherapy for intrahepatic cholangiocarcinoma. World J Gastrointest Onc. 2022; 14(8):1478–1489. doi: 10.4251/wjgo.v14.i8.1478. Available at: https://pubmed.ncbi.nlm.nih.gov/36160742/

Original research:

PANC Study (Pancreatitis: A National Cohort Study): A national cohort study examining the first 30-days from presentation of acute pancreatitis in the UK. BJS Open. 2023; 7(3):zrad008. doi: 10.1093/bjsopen/zrad008. Available at: https://pubmed.ncbi.nlm.nih.gov/37161673/

Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial. Int J Surg. 2022; 104:106737. doi: 10.1016/j.ijsu.2022.106737. Available at: https://pubmed.ncbi.nlm.nih.gov/35835346/

The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial. HPB (Oxford). 2020; 22(8):1112–1120. doi: 10.1016/j.hpb.2019.11.011. Available at: https://pubmed.ncbi.nlm.nih.gov/31974837/

Ward-based Goal-Directed Fluid Therapy (GDFT) in Acute Pancreatitis (GAP) trial: study protocol for a feasibility randomised controlled trial. BMJ Open. 2019; 9(10):e028783. doi: 10.1136/bmjopen-2018-028783. Available at: https://pubmed.ncbi.nlm.nih.gov/31601585/

Cardiac output Optimisation following Liver Transplant (COLT) trial: study protocol for a feasibility randomised controlled trial. Trials. 2018; 19(1):170. doi: 10.1186/s13063-018-2488-8. Available at: https://pubmed.ncbi.nlm.nih.gov/29514697/

Basic science and immunology:

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes. J Exp Med. 2020; 217(9):e20200050. doi: 10.1084/jem.20200050. Available at: https://pubmed.ncbi.nlm.nih.gov/32602903/

Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS. Nature. 2023; 614(7947):334–342. doi: 10.1038/s41586-022-05645-6. Available at: https://pubmed.ncbi.nlm.nih.gov/36697826/

Human liver memory CD8+ T cells use autophagy for tissue residence. Cell Reports. 2020; 30(3):687–698.e6. Available at: https://pubmed.ncbi.nlm.nih.gov/31968246/

Clinical outcomes and comparative studies:

Assessing the Impact of Primary Tumour Location on Survival After Resection of Colorectal Liver Metastases: A Propensity Weighted Retrospective Cohort Study. World J Surg. 2022; 46(7):1734–1755. doi: 10.1007/s00268-022-06514-z. Available at: https://pubmed.ncbi.nlm.nih.gov/35325347/

Randomised trial of enteral feeding in patients discharged from hospital following surgical resection of an upper gastrointestinal malignancy. Clin Nutr. 2017; 36(6):1516–1519. doi: 10.1016/j.clnu.2016.10.022. Available at: https://pubmed.ncb

Book chapters:

Liver Ischaemia-Reperfusion Injury. In: Liver Diseases: A Multidisciplinary Textbook. Springer, 2020. p129–141.

Surgery in Liver Disease. In: Liver Diseases: A Multidisciplinary Textbook. Springer, 2020. p769–783.