Current studies

HIV studies

BIC CNS:

Brain connectivity and patient reported outcomes in people with HIV (PWH) with symptoms of insomnia switching integrase inhibitor-based ART; a randomised controlled study.

BIC CNS Study - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Alan Winston

LAPTOP - Late Presenter Treatment Optimisation Study:

An Open-Label, Multi-Centre, Randomised Study to Investigate Integrase Inhibitor Versus Boosted Protease Inhibitor Antiretroviral Therapy for Patients with Advanced HIV Disease. The Late Presenter Treatment Optimisation Study (LAPTOP).

LAPTOP - Late Presenter Treatment Optimisation Study - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Alan Winston

The RIO trial: 

A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART

The RIO Trial - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Sarah Fidler
Funder: Bill & Melinda Gates Foundation

POPPY Waves 4 & 5: 

A prospective, observational study to examine the effects of ageing on the clinical outcomes of people living with HIV in England and Ireland - Waves 4 and 5 POPPY 4 & 5 – ‘Pharmacokinetic and Clinical Observations in People over Fifty Waves 4 and 5

POPPY Waves 4 & 5 - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Alan Winston

SHIP study (previously known as the HiPPY study):

Cervical screening and Human Papilloma Virus testing in young women with perinatally acquired HIV (SHIP Study).

HiPPY Study - Health Research Authority (hra.nhs.uk)

Principal investigators: Dr Tamara Elliot and Dr Merle Henderson
Funders: British HIV Association (BHIVA) and Imperial College charitable Trust

DOLOMITE:

A Cohort Study to assess DTG Safety in HIV Pregnant Women

DOLOMITE: A Cohort Study to assess DTG Safety in HIV Pregnant Women - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Graham Taylor

SEPAC:

Screening and Early Detection to Prevent Anal Cancer; development of a biomarker screening tool

The highest risk group for anal cancer is HIV-positive men-who-have-sex-with-men (MSM) with an estimated incidence of 70–130/100,000. This is 2 to 4 times the rate of cervical cancer in the UK at the time that the cervical screening was introduced in the 1980s.

Unlike cervical disease, there is no national screening programme for anal cancer. However, the pathogenesis of anal cancer has similarities to cervical cancer including the association with human papillomavirus (HPV) infection (>80% are HPV16 positive) and a pre-cancer phase characterised by anal intraepithelial neoplasia (AIN). The gold-standard test for AIN is high-resolution anoscopy (HRA) and biopsy, analogous to cervical colposcopy, requiring specific training. HRA as primary screening has never been implemented; it is burdensome for patients, expensive and difficult to resource.

This study aims to develop and evaluate a primary screening tool for anal pre-cancer that would allow the identification and treatment of early disease, thus reduce the morbidity and mortality associated with anal cancer. We will recruit 1000 HIV-positive MSM aged 40 years or older from five participating HIV clinics across England. All participants will undergo HRA and have samples taken for biomarker analysis.

SEPAC - Health Research Authority (hra.nhs.uk)

Principal investigator: Dr John Walsh

Positive voices: 

Development and Implementation of Positive Voices: the National Survey of People Living with HIV

Development and validation of a national survey of people with HIV - Health Research Authority (hra.nhs.uk)

Principal investigator: Dr Nicola Mackie

Sexual Health studies

UK Acute Cohort for Hepatitis C:

UK Cohort for Acute Hepatitis C: A prospective, multicentre, observational, cohort study of Acute Hepatitis C in the United Kingdom

UK Acute Cohort for Hepatitis C - Health Research Authority (hra.nhs.uk)

Principal investigator: Prof Graham Cooke

EAGLE1: 

BTZ116577-Treatment of Uncomplicated Urogenital Gonorrhoea

BTZ116577-Treatment of Uncomplicated Urogenital Gonorrhoea - Health Research Authority (hra.nhs.uk)

Principal investigator: Dr Borja Mora-Peris

COVID and other Infectious Diseases studies

PEARL: 

Prospective Cohort for Early Detection of Liver Cancer

Pearl - Health Research Authority (hra.nhs.uk)

Principal investigator: Dr Nowlan Selvapatt (hepatology team)
Departmental investigator: Prof Graham Cooke