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Dani Mufti, secretary
Dr Kwan is a UK-trained stroke specialist. He received his specialist training in general internal medicine and geriatric medicine in Wessex (UK), clinical neurology fellowship at Queen Square London (Institute of Neurology, University College London), and plant-based nutrition at Cornell University (USA). From 2006 to 2013, he worked as the stroke consultant and head of department of stroke medicine at the Royal Bournemouth Hospital, and the clinical lead for the Dorset Stroke Network. In 2009, he was appointed as a visiting professor in medicine at Bournemouth University. In December 2013, Dr Kwan travelled overseas and was appointed as a clinical associate professor and honorary consultant in geriatric medicine at the University of Hong Kong (HKU), developing a second specialist interest in dementia. At HKU, he founded the HKU Gerontology Research Laboratory and is primary investigator (PI) for several dementia, heart and brain cohorts; he currently has two postgraduate students in HKU involved in biomedical and clinical PhD projects, and ongoing collaborations with UCSF and UCL. In May 2018, Dr Kwan returned to the UK as a consultant stroke physician at Charing Cross Hospital. He remains as a visiting professor at Bournemouth University and an honorary clinical associate professor at the HKU.
His current clinical and research interests are hyperacute stroke interventions and post-stroke cognitive impairment, respectively.
Stroke, transient ischemic attack (TIA), dementia, geriatric medicine
Research & publications
- Post-stroke cognitive impairment
Publications since 2016:
Wong A, Black SE, Yiu SYP, Au LWC, Lau AYL, Soo YOY, Chan AYY, Leung TWH, Wong LKS, Kwok TCY, Cheung TCK, Leung KT, Lam BYK, Kwan JSK, Mok VCT. Converting MMSE to MoCA and MoCA 5 minute protocol in an educationally heterogenous sample with stroke or transient ischaemic attack. Int J Geriatr Psychiatr 2018;33(5):729-34. doi: 10.1002/gps.4846
Ho RTH, Fong TCT, Hon T, Chan WC, Kwan JSK, Chiu PKC, Lam LCW. Hui ES, Mak HKF. Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments. Aging Ment Health 2018 Mar 8:1-7. doi: 10.1080/13607863.2018.1442414.
Lau KK, Wong YK, Teo KC, Chang RSK, Tse MY, Hoi CY, Chan CY, Chan OL, Cheung RHK, Wong EKM, Kwan JSK, Hui ES, Mak HKF. Long-term implication of microbleeds in Chinese patients with ischaemic stroke. J Am Heart Assoc. 2017 Dec 7;6(12). pii: e007360. doi: 10.1161/JAHA.117.007360.
Kwan JSK, Chiang LLW, Myint PK, Mak KFH, Lau GKK, Tse G, Wong A, Mok V. Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia. Cochrane Database of Systematic Reviews 2017 (in press).
Lam K, Kwan JSK, Kwan CW, Chong MLA, Lai CKY, Luo WQV, Leung AYM, Liu JYW, Xue B, Chi I. Factors associated with the trend of physical and chemical restraint use amongst long-term care facility residents in Hong Kong: data from an 11-year observational study. JAMDA 2017 Aug 23. pii: S1525-8610(17)30361-4. doi: 10.1016/j.jamda.2017.06.018.
Vassallo M, Mathie L, Sharma JC, Kwan J, Allen S. A comparative study of the use of three cognitive function screening tests on rehabilitation wards for older people. Eur Geriatr Med. 2017;8(1):54-8.
Leung DY, Lo SK, Leung AY, Lou VW, Chong AM, Kwan JSK, Chan WC, Chi I. Prevalence and correlates of abuse screening items among community-dwelling Hong Kong Chinese older adults. Geriatr Gerontol Int 2017;17(1):150-160 doi: 10.1111/ggi.12655.
Yeo JM, Tse V, Kung J, Lin HY, Lee YT, Kwan JSK, Yan BP, Tse G. Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances. J Basic Clin Physiol Pharmacol. 2017;28(3):191-200 doi: 10.1515/jbcpp-2016-0110.
Lam K, Leung MF, Kwan CW, Kwan JSK. Severe spastic contractures and diabetes mellitus independently perdict subsequent minimal trauma fractures among long-term care residents. JAMDA 2016;17(11):1025-30.
Lau BHP, Kwan JSK, Cheung KSL. Depression moderates the frailty-subjective health link among Chinese near Centenarians and centenarians. Am J Geriatr Psychiatr. 2016;24(9):753-61. doi:10.1016/j.jagp.2016.05.014.
Lau BHP, Cheung KSL, Kwan JSK. Overlap of frailty, comorbidity, disability and poor self rated health in community-dwelling near centenarians and centenarians. J Am Geriatr Soc. 2016;64(4):900-1.
Vassallo M, Poynter L, Sharma JC, Kwan JSK. Nutritional risk, body mass index and rehabilitation outcome in cognitively impaired vs. cognitively normal patients. European Geriatric Medicine 2016;7(2):122-6.
Price M, Gunther A, Kwan JSK. Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis. The Cochrane Database of Systematic Reviews 2016 Apr 21 doi: 10.1002/14651858. CD005501.pub4.
Vassallo M, Poynter L, , Kwan JSK, Sharma JC, Allen SC. A prospective observational study of outcomes from rehabilitation of elderly patients with moderate to severe cognitive impairment. Clin Rehabil 2016;30(9): 901-8.
Tse G, Yeo JM, Tse V, Kwan J, Sun B. Gap junction inhibition by heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in Langendorff-perfused mouse hearts. Mol Med Rep 2016;14(5):4069-74.
Allen SC, Wong GTC, Vassallo M, Kwan JSK. Potential for a Beneficial Effect of Theophylline on Extended Acute Inflammation: Review. Br J Pharma Res 2016;14(5):1-12.
Other relevant stroke & neuroscience papers:
Price M, Gunther A, Kwan JSK. Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis. The Cochrane Database of Systematic Reviews 2014 Aug 2;8:CD005501.
Shea YF, Chan TC, Chang SKR, Hon FKS, Kwan JSK, Chu LW. Rapidly progressive ataxia during rehabilitation and a difficult road to diagnosis J Am Geriatr Soc 2014;62(8):1609-10.
Sykes L, Wood E, Kwan JSK. Antiepileptic drugs for the primary and secondary prevention of seizures after stroke. The Cochrane Database of Systematic Reviews 2014 Jan 24;1:CD005398.
Kwan J, Horsfield G, Bryant T, Gawne-Cain M, Durward G, Byrne CD, Englyst NA. IL6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischaemic stroke. Experimental Gerontology 2013;48(9):960-5.
Poynter L, Kwan J, Vassallo M. How does cognitive impairment impact on functional improvement following the rehabilitation of elderly patients? International J Clin Practice 2013;67(8):811-815.
Marigold R, Tiwari D, Günther A, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. The Cochrane Database of Systematic Reviews 2013 Jun 5;6:CD008710. doi: 10.1002/14651858.CD008710.pub2.
Kwan J, Pickering RM, Kunkel D, Fitton C, Jenkinson D, Perry VH, Ashburn AM. Impact of stroke-associated infection on long term survival: a cohort study. J Neurol Neurosurg Psychiatry 2013;84(3):297-304.
Marigold R, Arias M, Vassallo M, Allen SC, Kwan J. Autonomic dysfunction in older people. Reviews in Clinical Gerontology 2011:21:28-44.
Poynter L, Kwan J, Ahie Sayer A, Vassallo M. Does cognitive impairment affect rehabilitation outcome? J Am Geriatr Soc 2011;59(11):2108-11.
Jupp B, Mallela SK, Kwan J, Allen S, Sharma JC, Vassallo M. Development and evaluation of the GEMS (gait, eyesight, mental state, sedation) tool as an aid to predict outcome after hospitalisation. Geriatrics and Gerontology International 2011;11(1):8-15.
Townend E, Tinson D, Kwan J, Sharpe M. “Feeling sad and useless”: an investigation into personal acceptance disability and its association with depression following stroke. Clinical Rehabilitation 2010;24(6):555-564.
Kwan J. Predicting the risk of post-stroke epilepsy – why and how? Nature Reviews Neurology 2010;6:532-3.
Kwan J, Wood E. Antiepileptic drugs for the primary and secondary prevention of seizures after stroke. The Cochrane Database of Systematic Reviews 2010, Issue 1.
Vassallo M, Mathie L, Sharma JC, Kwan J, Allen S. Falls risk factors in elderly patients with cognitive impairment on rehabilitation wards. Geriatrics & Gerontology International 2009;9(1):41-6.
Englyst N, Horsfield G, Kwan J, Byrne C. Aspirin resistance is associated with inflammation, ischaemic stroke severity, and poorer functional outcome at six months. Journal of Cerebral Blood Flow & Metabolism 2008;28(6):1196-1203.
Kwan J, Jenkinson D, Vassallo M, Englyst N, Perry VH. System infections after acute stroke. Aging Health 2008;491:85-94.
Burdridge P, Allen S, Vassallo M, Kwan J. Antiepileptic drugs for older people. Reviews in Clinical Gerontology 2008;18(1):1-12.
Poynter L, Kwan J, Ahie Sayer A, Vassallo M. Do cognitive impaired patients benefit from rehabilitation? Reviews in Clinical Gerontology 2008;1:53-64
Vassallo M, Mathie L, Sharma JC, Kwan J, Allen S. Falls risk assessment tools compared with clinical judgement: an evaluation in a rehabilitation ward. Age Ageing 2008;37:277-81.
Abbas MA, Guenther A, Galantucci S, Fawi G, Comi G, Kwan J, Corea F. Microbial risk factors of cerebrovascular diseases: potential therapeutic options. The Open Neurology Journal 2008;2:20-24.
Kwan J, Allen S. Documenting the cause of death on the death certificate – can the accuracy be improved? Clinical Governance Bulletin 2007;6:19-20.
Kwan J, Hand P. Infections after acute stroke is associated with poor short-term outcome. Acta Neurologica Scand 2007;115:331-338.
Kwan J. Care pathways for acute stroke care and stroke rehabilitation – from theory to evidence. J Clin Neurosci 2007;14(3):189-200.
Abbas MA, Guenther A, Galantucci S, Fawi G, Comi G, Kwan J, Corea F. Factores de riesgo microbiológicos para enfermedades cardio y cerebrovasculares: potenciales opciones terapéuticas. Anuario Medico 2007, No 15 (of Rosario Argentina) - http://www.villavicencio.org.ar/pdf07/105.pdf.
Kwan J, Guenther A. Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis. The Cochrane Database of Systematic Reviews 2006, Issue 3.
Kwan J, Hand P, Dennis M, Sandercock P. Early stroke progression in the acute recovery period – clinical characteristics and impact on outcome. Quarterly J Medicine 2006;99:625-633.
Hand P, Kwan J. The challenge of thrombolysis for acute ischaemic stroke: can we treat more patients? Intern Med J 2006;36(8):477-8.
Corea F, Gunther A, Kwan J, Petzold A, Debette S, Sessa M, Silvestrelli G, Parnetti L, Tambasco N. The educational approach on stroke training in Europe. Clin Exp Hypertens 2006;28:433-7.
Townend E, Tinson D, Kwan J, Sharpe M. Fear of recurrence and beliefs about preventing recurrence in persons who have suffered a stroke. J Psychosomatic Res 2006;61(6):747-55.
Hand P, Kwan J, Lindley R, Dennis M, Wardlaw J. Improving the bedside assessment of suspected stroke – The Brain Attack Study. Stroke 2006;37:769-775.
Hand P, Haisma J, Kwan J, Lindley R, Lamont B, Dennis M, Wardlaw J. Inter-observer agreement for the clinical assessment of brain attack. Stroke 2006;37:776-780.
Kwan J, Sandercock P. In-hospital care pathways for stroke: an updated Cochrane review. Stroke 2005;36:1348-1249.
Kwan J, Hand P, Sandercock P. A systematic review of the effectiveness of interventions to improve the efficiency of delivering thrombolysis for acute stroke. Quarterly Journal of Medicine 2004;97:273-279.
Kwan J, Hand P, Sandercock P. A systematic review of barriers to efficient acute stroke care. Age Ageing 2004;33(2):116-121.
Kwan J, Sandercock P. In-hospital care pathways for stroke (Updated Review). The Cochrane Database of Systematic Reviews 2004, Issue 4.
Kwan J, Hand P, Dennis M, Sandercock P. Effects of introducing an integrated care pathway in an acute stroke unit. Age Ageing 2004;33:362-367.
Stone J, Townend E, Kwan J, Haga K, Dennis MS, Sharpe M. Personality change after stroke: some preliminary observations. J Neurol Neurosurg Psychiatry 2004;75(12):1708-13.
Sandercock P, Berge E, Dennis M, Forbes J, Hand P, Kwan J, Lewis S, Neilson A, Lindley R, Thomas B, Wardlaw J. Cost-effectiveness of thrombolytic with recombinant tissue plasminogen activator (rt-PA) for acute ischaemic stroke in the NHS. Stroke 2004;35(6):1490-8.
Kwan J, Lunt M, Jenkinson D. Assessing dynamic cerebral autoregulation after stroke using a novel technique of combining transcranial Doppler ultrasonography and rhythmic handgrip. Blood Pressure Monitoring 2004;9(1):3-8.
Kwan J, Sandercock P. In-hospital care pathways for stroke: a Cochrane systematic review. Stroke 2003;34(2):587-588.
Kwan J, Sandercock P. In-hospital care pathways for stroke (Original Cochrane review). The Cochrane Database of Systematic Reviews 2002, Issue 3.
Kwan J, Dennis M. Integrated care pathways for stroke. Geriatr Med 2002;5:51-53.
Kwan J, Sandercock P. Review: In-hospital care pathways for acute stroke do not improve clinical outcomes and lower quality of life. ACP Journal Club 2002;137(2):77.
Kwan J. Clinical epidemiology of stroke. CME J of Geriatr Med 2001;3(3):94-98.
Sandercock P, Berge E, Dennis M, Forbes J, Hand P, Kwan J, Lewis S, Neilson A, Lindley R, Thomas B, Wardlaw J. A systematic review of the effectiveness, cost-effectiveness and barriers to implementation of thrombolytic and neuroprotective therapy for acute ischaemic stroke in the NHS (HTA Report). Health Technology Assessment 2002;6(26):1-112.