Dr Gordon received his medical degree from St Bartholomew's Medical School in 1993 and then undertook his postgraduate medical training across the north Thames regions with an additional year spent at The Royal North Shore Hospital in Sydney, Australia. He was awarded the fellowship of the Royal College of Anaesthetists in 1999 and returned to Bart's to obtain his research doctorate examining genetic susceptibility in sepsis. Having obtained a dual CCST in anaesthesia and intensive care medicine he was awarded the Intensive Care Society visiting fellowship in 2005 and spent two years in Vancouver at St Paul's Hospital, University of British Columbia as a post-doctorate fellow. During this time he also worked as the director of medical development of a university spin-out company developing pharmacogenetic tests for use in the ICU. Dr Gordon returned to Imperial College Healthcare NHS Trust as a consultant in critical care medicine in November 2007, and was a recipient of a clinician scientist fellowship award from the National Institute for Health Research. Dr Gordon is also a director of research for the Intensive Care Foundation.


Critical illness, sepsis, post-operative care, emergency medicine, acute medicine

Research & publications

Clinical and translational studies in sepsis, early vasopressin use in septic shock and its interaction with corticosteroids, levosimendan for the prevention of organ failure, the use of metabonomic analysis to develop novel sepsis diagnostics in peri-operative and critical care.

Selected publications:

Herrmann IK, Bertazzo S, O'Callaghan DJP, et al., 2015, Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation, Nanoscale, Vol:7, ISSN:2040-3364, Pages:13511-13520

O'Callaghan DJP, O'Dea KP, Scott AJ, et al., 2015, Monocyte Tumor Necrosis Factor-alpha-Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation, Critical Care Medicine, Vol:43, ISSN:0090-3493, Pages:1375-1385

Rautanen A, Mills TC, Gordon AC, et al., 2015, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, Lancet Respiratory Medicine, Vol:3, ISSN:2213-2600, Pages:53-60

Gordon AC, Mason AJ, Perkins GD, et al., 2014, Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH), Bmj Open, Vol:4, ISSN:2044-6055

Orme RML, Perkins GD, McAuley DF, et al., 2014, An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial, Trials, Vol:15, ISSN:1745-6215

Gordon AC, Mason AJ, Perkins GD, et al., 2014, The interaction of vasopressin and corticosteroids in septic shock: A pilot randomized controlled trial, Critical Care Medicine, Vol:42, ISSN:0090-3493, Pages:1325-1333

Gordon AC, Wang N, Walley KR, et al., 2012, The Cardiopulmonary Effects of Vasopressin Compared With Norepinephrine in Septic Shock, Chest, Vol:142, ISSN:0012-3692, Pages:593-605

Gordon AC, Russell JA, Walley KR, et al., 2010, The effects of vasopressin on acute kidney injury in septic shock, Intensive Care Medicine, Vol:36, ISSN:0342-4642, Pages:83-91

Russell JA, Walley KR, Gordon AC, et al., 2009, Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock, Critical Care Medicine, Vol:37, ISSN:0090-3493, Pages:811-818

Wurfel MM, Gordon AC, Holden TD, et al., 2008, Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis, American Journal of Respiratory and Critical Care Medicine, Vol:178, ISSN:1073-449X, Pages:710-720

Russell JA, Walley KR, Singer J, et al., 2008, Vasopressin versus norepinephrine infusion in patients with septic shock, New England Journal of Medicine, Vol:358, ISSN:0028-4793, Pages:877-887

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