Surgery research trials
Find out about our current, on-going, surgery research trials
Surgery - a wide variety of surgeries including brain, breast, gastrointestinal and gynaecological.
This trial will look at collecting data to show that a device called the iKnife can be used to tell surgeons immediately whether the tissue they are cutting is cancerous or not in real time.
Current methods used for identification of healthy and unhealthy tissue include sending samples to the laboratory for examination during the operation, or taking biopsies for analysis after the procedure.
The iKnife is based on electrosurgery, a technology invented in the 1920s that is commonly used today. Electrosurgical knives use an electrical current to rapidly heat tissue, cutting through it while minimising blood loss. In doing so, they vaporise the tissue, creating smoke that is normally sucked away by extraction systems.
This smoke is then passed through a machine (mass spectrometer) that analyses it. By measuring the weight of individual smoke particles the machine can determine what sort of tissue is being cut at the same time that the smoke is produced, instantly providing information that normally takes up to half an hour to reveal using laboratory tests.
The aim of the iKnife is help guide the surgeon to perform more precise operations and to reduce the number of patients requiring more surgery because of missed cancerous tissue.
Who can take part?
Patients undergoing surgery in brain, breast, gastrointestinal and gynaecological
Edward St John
The aim of this study is to look at whether patients who wear elastic stockings as well as taking anticoagulant medication, which thin the blood so it cannot form harmful clots, have a lower chance of developing venous thromboembolism (VTE) than patients who take anticoagulant medications only.
Doctors have known about the risks of patients developing VTE after operations for many years and use two main ways to prevent this:
Doctors are not sure if wearing elastic stockings on top of blood thinners reduces the risk of VTEs any more than if the blood thinners are given on their own. This study is being done to find out if this is true.
1) elastic stockings plus blood thinner’ group or
Who can take part
Elective surgical inpatients over the age of 18 assessed as being at moderate or high risk of VTE. Exclusions apply.
Participants attend follow up appointments after 1 and 2-3 weeks, as well as 90 days after surgery, to have their legs scanned to check for the presence of any blood clots.
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