Find out about our current, on-going, ophthalmology research trials

Trial: DARC 2 study

Research area



Like all cells, retinal cells have a life span and a number of them will be dying or sick at any given time. This process is called apoptosis. Detection of apoptosing retinal cells (DARC) is a methodology that involves injecting into a vein a special fluorescent dye that binds to cells that are sick, enabling doctors to use a powerful camera to identify sick cells in the retina. By being able to see the sick cells, doctors can get a sense of the rate of apoptosis – if the rate is higher than normal, this could point to a degenerative process like the ones seen in glaucoma, optic neuritis, age-related macular degeneration and even Alzheimer’s disease. This study aims to investigate the efficacy of the DARC methodology described above to identify sick retinal cells in both healthy volunteers and those affected by conditions such as glaucoma, optic neuritis, and age-related macular degeneration. 

Who can take part?

We’re recruiting men and women aged 18 and over with healthy eyes.


Serge Miodragovic, clinical trials manager

Phone: 020 3312 3206